For Research Purposes Only: This product is strictly intended for laboratory research and in vitro studies. It is not meant for human or animal use of any kind, and introduction into the body is strictly prohibited by law. All information provided on this website is for educational reference only. This product must be handled exclusively by licensed, qualified professionals. It is not classified as a drug, food, or cosmetic and must not be misrepresented or used as such.

GHK-CU 50MG

GHK-CU 50MG

GHK-CU 50MG Vial delivers a high-purity preparation of the well-characterized copper tripeptide GHK-Cu (glycyl-L-histidyl-L-lysine–copper). Naturally occurring in human plasma, saliva, and urine, this peptide–metal complex is widely used in advanced research models exploring tissue regeneration, extracellular matrix remodeling, and oxidative balance. Presented as a stabilized vial format, GHK-CU 50MG is designed for controlled, reproducible in vitro and in vivo laboratory applications where precise dosing, structural consistency, and robust copper chelation are critical to study design.

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DESCRIPTION

Overview

– Naturally occurring **glycyl-L-histidyl-L-lysine–copper (GHK-Cu)** tripeptide complex
– Investigated in models of **wound repair**, **tissue remodeling**, and **skin biology**
– Explored for effects on **collagen and elastin** dynamics and extracellular matrix support
– Studied for **antioxidant** and **metal-chelating** properties relevant to oxidative stress
– Supplied as a **50 mg vial** to support accurate dosing in research protocols

Structure

GHK-Cu is a **copper(II) complex** of the tripeptide **glycyl-L-histidyl-L-lysine**. The linear peptide sequence (Gly–His–Lys) provides nitrogen donor atoms from the histidine imidazole ring and peptide backbone that coordinate a divalent copper ion in a square-planar or distorted square-pyramidal geometry. This coordination environment confers high affinity for Cu(II) and stabilizes the complex in aqueous systems, enabling GHK-Cu to function as a biologically relevant low–molecular weight copper carrier. The peptide moiety has the empirical formula C₁₄H₂₄N₆O₄, which, together with Cu(II), forms the GHK-Cu complex.

Research

GHK-Cu is widely studied as a low–molecular weight copper carrier implicated in tissue repair, extracellular matrix modulation, and cellular stress responses. In experimental systems, the complex has been associated with regulation of collagen and glycosaminoglycan turnover, fibroblast and endothelial cell behavior, and angiogenic signaling. Its copper-binding capacity and redox activity underpin interest in oxidative balance and cytoprotective pathways. Ongoing research leverages GHK-Cu to probe gene-expression programs, inflammatory mediators, and matrix-remodeling cascades within skin, connective tissue, and neurobiological models.

Referenced Citations

Pickart, L., & Margolina, A. (2018). Regenerative and protective actions of the GHK-Cu peptide in the light of the new gene data. *International Journal of Molecular Sciences, 19*(7), 1987. https://doi.org/10.3390/ijms19071987

Pickart, L. (2008). The human tri-peptide GHK and tissue remodeling. *Journal of Biomaterials Science, Polymer Edition, 19*(8), 969–988. https://doi.org/10.1163/156856208784909435

McCormack, J. P., & Weaver, D. F. (2015). Bioactive copper complexes in neurobiology and medicine. *Chemical Reviews, 115*(21), 11647–11679. https://doi.org/10.1021/cr500529v

Pickart, L., & Thaler, M. M. (1973). Tripeptide in human serum which prolongs survival of normal liver cells and stimulates growth in neoplastic liver. *Nature, 243*(5400), 85–87. https://doi.org/10.1038/243085a0